It has been said that "we read best what we read most". This quote was used as a type specimen in Emigre magazine in the late 1980's by Zuzana Licko. It was written in defense of her typefaces, whose elemental shapes—designed with the strictures of the early HP laser printer in mind—challenged the commonly held notions of what made typefaces legible.
The paradigm shift—wrought by the personal computer, Postscript and desktop publishing—should have had a massive impact on the shapes of our typographic characters, just as the advances of the World Wide Web further changed the way we viewed words (even though letterforms change at the pace of the most conservative reader). Thus, radical innovations like Kurt Schwitters' Systemschrift, (a phoenetic alphabet from 1927), are doomed to fail.